2-CHLOROPYRIMIDINE-4-BORONIC ACID PINACOL ESTER
2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
CAS: 1310404-27-3
Molecular Formula: C10H14BClN2O2
2-CHLOROPYRIMIDINE-4-BORONIC ACID PINACOL ESTER - Names and Identifiers
2-CHLOROPYRIMIDINE-4-BORONIC ACID PINACOL ESTER - Physico-chemical Properties
| Molecular Formula | C10H14BClN2O2 |
| Molar Mass | 240.49 |
| Density | 1.19±0.1 g/cm3(Predicted) |
| Boling Point | 369.1±15.0 °C(Predicted) |
| pKa | -1.74±0.32(Predicted) |
| Storage Condition | Room Temprature |
| Sensitive | Irritant |
| MDL | MFCD07367539 |
2-CHLOROPYRIMIDINE-4-BORONIC ACID PINACOL ESTER - Introduction
2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine is an organic compound with the chemical formula C11H14BClN2O2. It is a white crystalline solid which is soluble in organic solvents such as dimethylformamide and dichloromethane.
2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine has a wide range of applications in organic synthesis. It is commonly used in the coupling reaction and the introduction of hydroxyl protection groups in organic synthesis reactions. In addition, it can also be used as an intermediate in the field of pesticides and pharmaceuticals.
The method for preparing 2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine includes the following steps:
1. Reaction of hydrogen dibromide with 4,4,5,5-tetramethyl-1,3,2-dioxaborolan in an organic solvent at low temperature to generate 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl chloride;
2.4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl chloride is reacted with 2-bromoacetamide in the presence of a base to produce 2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine.
Regarding safety information, the specific safety of 2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine needs further research. During use, it is recommended to follow laboratory safety procedures and wear appropriate protective equipment, such as gloves and protective glasses. During storage and handling, contact with oxidants and strong acids should be avoided as much as possible. At the same time, when disposing of waste, it should be disposed of in accordance with local regulations.
2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine has a wide range of applications in organic synthesis. It is commonly used in the coupling reaction and the introduction of hydroxyl protection groups in organic synthesis reactions. In addition, it can also be used as an intermediate in the field of pesticides and pharmaceuticals.
The method for preparing 2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine includes the following steps:
1. Reaction of hydrogen dibromide with 4,4,5,5-tetramethyl-1,3,2-dioxaborolan in an organic solvent at low temperature to generate 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl chloride;
2.4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl chloride is reacted with 2-bromoacetamide in the presence of a base to produce 2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine.
Regarding safety information, the specific safety of 2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine needs further research. During use, it is recommended to follow laboratory safety procedures and wear appropriate protective equipment, such as gloves and protective glasses. During storage and handling, contact with oxidants and strong acids should be avoided as much as possible. At the same time, when disposing of waste, it should be disposed of in accordance with local regulations.
Last Update：2024-04-09 21:11:58
